Unfortunately, many things can worsen Melasma. Strong wind, coldness, heat, massage, creams, acid peels, dermarolling etc. However, it is highly individual. Not everybody reacts the same. Acid peels, dermarolling, laser treatments etc. often improve Melasma but in some unfortunate cases, it worsens Melasma (the skin produces more melanin pigment as a reaction to the treatment). What improves Melasma in one person can make it worse in another. Always do a test patch.
It will be difficult to find out what caused the worsening of your Melasma. Theoretically, it could have been the vit. C in spite of the fact that ascorbic acid (vit. C) has been successfully used in improving Melasma because it is a mild inhibitor of melanin (see the studies below). It could also have been the dermaroller. I think you should stop both the vit. C and the dermaroller and use only Hydroquinone cream.
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma Liliana Elizabeth Espinal-Perez MD, Benjamin Moncada MD*, Juan Pablo Castanedo-Cazares MD
AbstractBackground Melasma is an acquired treatment-resistant hyperpigmentation of the skin.
Methods Sixteen women with idiopathic melasma were included in our trial. After randomization by another clinician, they were instructed to use, at night, 5% ascorbic acid cream on one side of the face and 4% hydroquinone cream on the other side, for 16 weeks. Sunscreen was applied daily throughoutthe period of observation. They were evaluated every month by colorimetry, digital photography, and regular color slides. Subjective evaluation by each patient was also taken into account.
Results The best subjective improvement was observed on the hydroquinone side with 93% good and excellent results, compared with 62.5% on the ascorbic acid side (P < 0.05); however, colorimetric measures showed no statistical differences. Side-effects were present in 68.7% (11/16) with hydroquinone vs. 6.2% (1/16) with ascorbic acid.
Conclusion Although hydroquinone showed a better response, ascorbic acid may play a role in the therapy of melasma as it is almost devoid of side-effects; it could be used alone or in combination therapy.
A Randomized, Double-Blind, Placebo-Controlled Trial of Vitamin C Iontophoresis in Melasma Huh C-H, Seo K-I, Park J-Y, Lim J-G, Eun H-C, Park K-C
AbstractBackground Vitamin C is known to both inhibit melanin formation and reduce oxidized melanin. However, vitamin C does not easily penetrate the skin. In this study, vitamin C iontophoresis was employed in order to enhance vitamin C penetration.
Objective: The purpose of this study was to evaluate the efficacy of vitamin C iontophoresis for melasma patients. Methods: Twenty-nine females with melasma were enrolled. For iontophoresis, a vitamin C solution was applied to one side of the face, while distilled water was applied to the other side as a control. The L (luminance) value was measured by a colorimeter to obtain an objective pigmentation parameter.
Results: Twelve weeks after iontophoresis, the colorimeter of the treated site showed a significant decrease in the L value (from 4.60 to 2.78, p = 0.002), compared to that of the control site (from 4.45 to 3.87, p = 0.142).
Conclusion: Vitamin C iontophoresis may be an effective treatment modality for melasma.
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